bolaturbo & bola turbo
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Although it doesn't have the depth of some animated masterpieces, "Turbo" is fun-filled enough to satisfy the audience. The characters are likable, as well. Turbo, the protagonist, is ambitious, funny, and adventurous. His brother, Chet, is a little more cautious but still very fun. Lastly, the other snails that become Turbo's friends are hilarious and add to the story.
Although "Turbo" may not have as much depth as some of the more complex animated films, it is still a fun-filled adventure about a fast snail racing in the middle of a bunch of monstrous cars. Moreover, the character development is great and the animation is slick. This is definitely a film to watch!.
To identify the targets of the Bolaturbo & bola turbo transcriptional regulator BolA, we performed chromatin immunoprecipitation followed by DNA high-throughput sequencing (ChIP-seq). Chromatin from an E. coli strain whose bolA gene was deleted (DbolA) and an isogenic strain expressing a chromosomal fusion of the bolA protein with a 3xFlag tag (wt 3xFlag) were subjected to ChIP-seq. Statistically significant peaks corresponding to the BolA binding sequences were identified. A DNA consensus binding motif was determined based on the pool of DNA sequences corresponding to the peaks.
The results from ChIP-seq showed that BolA directly binds to the promoter regions of several genes. Among these, the genes encoding for fimbriae and other adhesion proteins were most prominently induced upon overexpression of BolA (bolA++ strain). In addition, the expression levels of the genes ydeS, yfcV, ygiL, yadC, ybgD, yraH, and yehC increased by 3 h after induction of bolA expression. These genes are known to be involved in the early steps of biofilm formation, including the formation of type I fimbriae (see Fig. S1A in the supplemental material).
Furthermore, it was found that the BolA protein regulates central carbon metabolism by causing the direct activation of transcription of genes for amino acid pathways and the TCA cycle. These cellular pathways are connected to peptidoglycan synthesis, which is an important component of the bacterial cell wall. Thus, the regulation of these metabolic pathways by BolA is a general mechanism for the establishment of biofilms.
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